3rd ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3)
Cet article présente les recommandations, issues d'une conférence internationale de consensus, sur la prise en charge d'un cancer du sein de stade avancé
Advanced Breast Cancer (ABC) comprises both locally advanced (LABC) and metastatic breast cancer (MBC). Although treatable, MBC remains an incurable disease with a median overall survival of ∼2–3 years and a 5-year survival of only ∼25% [2–4]. Some more recent series seem to indicate an improvement in median overall survival.
A recent comprehensive report of the advances in this field in the last decade shows that progress has been slow in terms of improved outcomes, quality of life, awareness and information regarding ABC.
The level of evidence used to base many recommendations remains low, and more and better designed trials are needed to address clinically important questions. An improved understanding of the biology of ABC, its heterogeneity, and of the mechanisms of resistance to the different types of therapies is being acquired and it is anticipated that the application of new technologies, such as next generation sequencing, patient xenographs, systems biology, and computer modelling, among others, will accelerate advances.
Aiming at providing clinically oriented guidelines on how to best manage ABC, the 3rd International Consensus Conference for Advanced Breast Cancer (ABC 3) took place in Lisbon, Portugal on November 5th–7th, 2015, bringing together over 1100 participants from 84 countries, including health professionals, patient advocates and journalists.
The ABC guidelines are developed as a joint effort from ESO (European School of Oncology) and ESMO (European Society of Medical Oncology), and are endorsed by EUSOMA (European Society of Breast Cancer Specialists), ESTRO (European Society of Radiation Oncology), UICC (Union for International Cancer Control), SIS (Senologic International Society) and FLAM (Federatión LatinoAmericana de Mastologia). There was also official representation of ASCO (American Society of Clinical Oncology) in the consensus panel. The ABC Conference was also organized under the auspices of…
Annals of Oncology , résumé, 2015