American Society of Clinical Oncology Perspective: Raising the Bar for Clinical Trials by Defining Clinically Meaningful Outcomes
Cet article présente des recommandations visant à relever le niveau d'exigence requis dans l'évaluation de nouveaux traitements du cancer
Cancer clinical trials have typically investigated agents or regimens in patients selected for study based primarily on tumor histology and clinical characteristics. This approach, when successful, has too often resulted in only small incremental improvements in overall survival (OS) that likely reflect the impact of agents with modest efficacy in a subset of the study population that is not readily identifiable. Although this work has improved the lives of countless patients...
Journal of Clinical Oncology , résumé, 2014