The Beginning of the End of the Beginning in Cancer Genomics
Menée sur 200 patients adultes atteints d'une leucémie myéloïde aiguë, cette étude du projet "The Cancer Genome Atlas" identifie la fréquence des mutations de divers gènes et met en évidence la complexité des événéments génétiques contribuant au développement de la maladie chez un individu
This is the age of massive genome surveys — at least for a little while longer. Sixty years after Watson and Crick's discovery, and a decade after the completion of the Human Genome Project, large-scale sequencing efforts directed at human disease abound, especially for cancer and rare congenital syndromes. International research teams supported by public funding agencies such as the National Institutes of Health and by private foundations such as the Wellcome Trust are rapidly enlarging the catalogue of genetic changes associated with neoplasia and other ailments, using ever faster, ever cheaper sequencing methods and heavy-duty bioinformatics...
New England Journal of Medicine , éditorial en libre accès, 2012