A case–control study of chronic prostatitis/chronic pelvic pain syndrome and colorectal cancer
A partir des données de registres de l'assurance maladie taïwanaise, cette étude cas-témoins évalue l'association entre une prostatite chronique ou un syndrome douloureux pelvien chronique et le risque de cancer colorectal (2 899 cas et 14 995 témoins)
Study Type – Symptom prevalence (case control)Level of Evidence 2bWhat's known on the subject? and What does the study add?Associations are well established between intestinal infection/inflammation or inflammatory bowel diseases and colorectal cancer (CRC).Our study found an association between CRC and previously diagnosed chronic prostatitis/chronic pelvic pain syndrome. Patients with CRC had a 1.45-fold higher risk of having a previous diagnosis of chronic prostatitis/chronic pelvic pain syndrome than controls. This phenomenon was found to be more prominent in subjects younger than 60 years. OBJECTIVE * •To estimate the association between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and colorectal cancer (CRC) using a nationwide population-based data set. PATIENTS AND METHODS * •This case–control study used data sourced from the Taiwan Longitudinal Health Insurance Database. * •The cases comprised 2899 patients with CRC and 14 995 randomly selected subjects as controls. * •We used conditional logistic regression to examine the association between CRC and previous diagnosis of CP/CPPS. RESULTS * •Of the sampled patients, 531(3.05%) had been diagnosed with CP/CPPS before the index date, with 123 (4.24% of the patients with CRC) coming from the cases and 408 individuals (2.81% of patients without CRC) coming from the controls. * •Conditional logistic regression analysis revealed that cases were more likely to have CP/CPPS than controls (odds ratio 1.45, 95% CI 1.17–1.79, P < 0.001) after adjusting for the monthly income, geographic location, urbanization level, hypertension, diabetes, renal disease, obesity and cystic kidney disease. * •In subgroup analysis, we found the magnitude of the association to be higher in subjects younger than 60 years (age 40–49, odds ratio 2.01; 95% CI 2.04–3.58 and aged 50–59, 2.40, 95% CI 1.48–3.87, both P < 0.001) than among other age groups. CONCLUSION * •We conclude that CP/CPPS patients are at higher risk for CRC, especially in males under 60 years of age.
British Journal of Urology International , résumé, 2011