RAIDDing ER Stress for Oncolytic Viral Therapy
Menée in vitro et in vivo, cette étude suggère que l'inhibition de la réponse au stress du réticulum endoplasmique permet d'augmenter les effets d'un virus oncolytique sur les cellules cancéreuses
Oncolytic viruses exploit molecular differences between normal and cancer cells to selectively kill the latter. Results of a synthetic lethal screen described in this issue of Cancer Cell demonstrate that components of the unfolded protein response (UPR) limit virus-induced tumor cell killing and identify a strategy to utilize this knowledge.
Cancer cell , commentaire, 2010