Reduced risk of breast, endometrial, and ovarian cancer in women with celiac disease
Menée en Suède, cette étude (17 852 cas et 88 400 témoins) évalue l'association entre une maladie coeliaque et le risque de cancer du sein, de l'endomètre et de l'ovaire
Background Women with celiac disease (CD) may be at decreased risk of female hormone-related cancers given the observed reduction in breast cancer seen in some cohorts. Methods Using biopsy data from all 28 pathology departments in Sweden, we identified 17,852 women with CD who were diagnosed between 1969 and 2007. We used Cox regression model to estimate their risk of breast, endometrial, and ovarian cancer and then compared them with 88,400 age- and sex-matched controls. Results Individuals with CD were at a lower risk for all three outcomes: breast cancer (Hazard ratio, HR=0.85; 95%CI=0.72-1.01), endometrial cancer (HR=0.60; 95%CI=0.41-0.86), and ovarian cancer (HR=0.89; 95%CI=0.59-1.34). This inverse relationship was strengthened when we excluded the first year of follow-up beyond CD diagnosis (breast: HR=0.82; 95%CI=0.68-0.99; endometrial: HR=0.58; 0.39-0.87; and ovarian cancer: HR=0.72; 0.45-1.15). Conclusion
International Journal of Cancer , résumé, 2010