Iron Oxide Nanoparticles for Targeted Cancer Imaging and Diagnostics
Cet article passe en revue les perspectives offertes par des agents de contraste superparamagnétiques à base de nanoparticles d'oxyde de fer pour l'imagerie des cancers
Superparamagnetic Iron Oxide Nanoparticles (SPIONs) have proven to be highly effective contrast agents for the MRI diagnosis of solid tumors. This review examines the various techniques that are available to selectively target SPIONs towards a wide variety of cancerous tissues, with specific attention given to how the surface properties imparted by various targeting ligands affect the particles tissue distribution and pharmacokinetics. An in-depth examination of the various human cell lines utilized to test the assorted targeting methods is also presented, as well as an overview of the various types of cancer that each targeting method has been utilized against for both in vivo and in vitro studies.
Nanomedicine : nanotechnology, biology, and medicine , résumé, 2010