Performance of clinical breast cancer risk prediction models versus a mammography-based artificial intelligence risk model
Menée à partir de mammographies numériques réalisées sur 12 308 femmes dont 250 ayant développé un cancer du sein dans les 5 années qui ont suivi, cette étude évalue, par rapport à trois modèles cliniques prédictifs, la performance d'un modèle d'apprentissage automatique pour prédire le risque de développer la maladie
Background : Artificial intelligence (AI) -based, mammography breast cancer (bc) risk prediction models show improved discriminatory accuracy relative to clinical risk models. However, data on their calibration are limited. This study compared model performance of three clinical bc risk models—Gail, Tyrer-Cuzick (TC) v8, and Breast Cancer Surveillance Consortium (BCSC) v3 - to the MIRAI AI-risk model.
Methods : Digital mammograms were ascertained from a screening mammography cohort of 12,308 women within the Mayo Clinic Biobank with 250 incident BCs (176 invasive) within five years. We predicted five-year bc risk, estimated discriminatory accuracy (concordance [C]-index) and calibration (observed to expected ratio [O/E]) of both overall and invasive bc, and compared estimates using bootstrapping approaches.
Results : MIRAI demonstrated similar or improved discriminatory accuracy of overall bc (C-index = 0.71, 95% confidence interval [CI]=0.68-0.74) and invasive bc (C-index = 0.71, 95%CI = 0.67-0.75) compared to clinical models (Overall bc: C-index = 0.59-0.68, Invasive bc: C-index = 0.60-0.68). MIRAI’s calibration for risk of overall bc (O/E = 0.96, 95%CI = 0.85-1.08) was improved compared to Gail (O/E = 1.22, 95%CI = 1.07-1.38) and BCSC (O/E = 1.38, 95%CI = 1.22-1.56) but similar to TC with volumetric percent density and polygenic risk score (O/E = 0.99, 95%CI = 0.87-1.13). However, for low-risk women (approximately 50%), MIRAI overestimated risk of overall bc. MIRAI also overestimated risk of invasive bc across the risk spectrum (O/E = 0.68, 95%CI = 0.58-0.78), while clinical models had good calibration (O/E = 0.86-0.99).
Conclusion : MIRAI demonstrated stronger discriminatory accuracy than clinical models for five-year overall and invasive bc risk prediction but overestimated risk for both bc endpoints. AI-based risk models should consider discriminatory accuracy and calibration for invasive cancer before implementation.
Journal of the National Cancer Institute , résumé, 2026