Impact of oxidative and antioxidative potential on cancer risk: the Japan Public Health Center-based Prospective Study
Menée au Japon auprès de 4 815 témoins et 4 718 patients atteints d'un cancer (durée moyenne de suivi : 15,5 ans), cette étude analyse l'association entre la concentration plasmatique de dérivés de métabolites réactifs de l’oxygène (d-ROM), le potentiel antioxydant biologique et le risque de développer la maladie
Background: This study aimed to elucidate the impact of systemic shifts towards increased oxidative or antioxidative potential on cancer development and suppression. Given that longitudinal studies on cancer associations are limited for plasma levels of derivatives of reactive oxygen metabolite (d-ROM) and biological antioxidant potential (BAP), we investigated the associations of these robust biomarkers with risk of overall and multiple site-specific cancers.
Methods: We designed a case-cohort study within a large Japanese population-based prospective study. Plasma d-ROM and BAP were measured in 4718 cancer cases and 4815 randomly selected subcohort individuals, who were followed for a mean period of 15.5 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using a weighted Cox proportional hazards model.
Results: Compared to the lowest quartiles, the highest quartiles of d-ROM showed a multivariable adjusted HR of 1.69 (95% CI = 1.08–2.64; ptrend = 0.02) for hepatocellular carcinoma and 1.32 (95% CI = 1.01–1.72; ptrend = 0.01) for lung cancer. Conversely, the highest quartile of BAP for gastric cancer was 0.80 (95% CIs = 0.63–1.01; ptrend = 0.03).
Conclusions: These findings suggest a potential impact of oxidation and antioxidation on cancer development at specific sites.
British Journal of Cancer , résumé, 2026