Serous Ovarian Cancer Following Opportunistic Bilateral Salpingectomy
Menée à partir de données canadiennes portant sur 85 823 femmes ayant subi une hystérectomie ou une ligature tubaire définitive entre 2008 et 2020, cette étude analyse l'effet d'une salpingectomie bilatérale opportuniste sur le risque de carcinome séreux de l'ovaire
Ovarian carcinoma is a heterogeneous disease with a 5-year survival rate below 50%.1 Primary prevention of the most common histotype of ovarian carcinoma (high-grade serous carcinoma [HGSC], 70% of ovarian carcinomas) is possible using opportunistic bilateral salpingectomy (OBS; the removal of the fallopian tubes during another pelvic surgery while conserving the ovaries). Significant data show that OBS is safe,2 it does not appear to reduce the age of onset of menopause,3 and it is cost-effective.4 Herein, this evidence base is expanded by (1) estimating the risk reduction for serous ovarian cancer afforded by OBS using population-based data; and (2) examining whether the histotype distribution of ovarian carcinomas in people without fallopian tubes significantly differs from the historical histotype distribution.
JAMA Network Open , article en libre accès, 2026