Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer
Menée à l'aide de modèles murins et d'échantillons tissulaires provenant de patientes atteintes d'un cancer du sein, cette étude met en évidence une corrélation entre la présence de macrophages FOLR2+ dans le stroma tumoral, l'infiltration de la tumeur par les lymphocytes T CD8+ et le pronostic
Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with distinct roles on cancer progression and antitumor immunity. Here, we identify a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors. FOLR2+ macrophages localize in perivascular areas in the tumor stroma, where they interact with CD8+ T cells. FOLR2+ macrophages efficiently prime effector CD8+ T cells ex vivo. The density of FOLR2+ macrophages in tumors positively correlates with better patient survival. This study highlights specific roles for tumor-associated macrophage subsets and paves the way for subset-targeted therapeutic interventions in macrophages-based cancer therapies.
Cell , résumé, 2021