CommNETs/NANETS guidelines for the diagnosis and management of patients with Lung Neuroendocrine Tumors: An international collaborative endorsement and update of the 2015 ENETS expert consensus guidelines
Cet article présente une mise à jour des recommandations de la "Commonwealth Neuroendocrine Tumour Research Collaboration" et du "North American Neuroendocrine Tumor Society" concernant le diagnostic et la prise en charge des tumeurs pulmonaires neuroendocrines
Introduction : Lung neuroendocrine tumors (LNETs) are uncommon cancers and there is a paucity of randomized evidence to guide practice. As a result, current guidelines from different neuroendocrine tumor societies vary considerably. There is a need to update and harmonise global consensus guidelines. This paper reports best practice guidelines produced by a collaboration between the Commonwealth Neuroendocrine Tumour Research Collaboration (CommNETs) and the North American Neuroendocrine Tumor Society (NANETS).
Methods : We performed a formal endorsement and updating process of the 2015 European Neuroendocrine Tumor Society (ENETS) expert consensus paper on LNET. A systematic review from January 2013 to October 2017 was conducted to procure the most recent evidence. The stepwise endorsement process involved experts from all major subspecialties, as well as patients and advocates. Guided by discussion of the most recent evidence, each statement from ENETS was either endorsed, modified, or removed. New consensus statements were added if appropriate.
Results : The search yielded 1,109 new publications of which 230 met the inclusion criteria. Twelve statements were endorsed, 22 statements were modified or updated, one was removed and two were added. Critical answered questions for each topic in LNET were identified.
Conclusions : Through the consensus process, guidelines for the management of patients with local and metastatic NETs have been updated to include both recent evidence and practice changes relating to technological and definitional advances. The guidelines provide clear, evidence-based statements aimed at harmonising the global approach to patients with LNETs, based on the principles of person-centered and LNET-specific care. The importance of LNET-directed research and person-centered care throughout the diagnosis, treatment, and follow-up journey is emphasized along with directions for future collaborative research.
Journal of Thoracic Oncology , résumé, 2019