Persistent salivary human papillomavirus DNA as a surveillance biomarker
Menée sur 124 patients atteints d'un carcinome oropharyngé associé au papillomavirus humain (HPV), cette étude évalue l'association entre la persistance de l'ADN du HPV de type 16 dans les rinçages buccaux et la survie des patients
In this issue of JAMA Oncology, Rettig and colleagues1 show that persistent oral HPV type 16 (HPV16) DNA, measured in pre- and posttreatment rinses of patients undergoing curative-intent therapy for HPV-positive OPSCC, is a harbinger of poor recurrence-free survival. Whereas their data are intriguing, an important clinical question is raised: Does the oral rinse, a noninvasive surveillance tool, identify subclinical local or locoregional recurrence (LRR) at a time amenable to surgical salvage?
JAMA Oncology , commentaire, 2014