Metastatic Recurrence in Adolescent and Young Adult Cancer—Key Drivers of Early Mortality
Menée à partir de données portant sur 48 406 adolescents et jeunes adultes atteints d'un cancer (âge médian au diagnostic : 33 ans), cette étude de cohorte rétrospective évalue l'incidence cumulée d'une récidive métastatique en fonction du stade de la maladie au diagnostic (43 935 cas de maladie non métastatique lors du diagnostic)
Survivors of adolescent and young adult cancer (aged 15 to 39 years at diagnosis) are a large and growing population at risk for early mortality, with death due to primary cancer recurrence/progression a large contributor to increased mortality among survivors.1-3 In JAMA Oncology, using linked data between the California Cancer Registry, Kaiser Permanente Northern California, and the Department of Health Care Access and Information, Brunson and colleagues4 report on patterns of metastatic recurrence among adolescents and young adults with cancer and compare the risk of death between those with metastatic recurrence and those with metastatic disease at diagnosis. These data provide valuable insights into the burden of metastatic disease among adolescents and young adults with cancer and identify cancer types for which adolescents and young adults face high risk for metastatic recurrence and associated mortality. Findings largely parallel trends in metastatic recurrent disease incidence and mortality among populations with broader age ranges, with some notable exceptions.
JAMA Oncology , éditorial, 2025