Hepatitis C Virus Infection and Pancreatic Cancer Risk in US Veterans
Menée à partir de données portant sur 6 330 856 vétérans américains (92,3 % d'hommes ; âge médian : 61,6 ans), cette étude analyse l'association entre une infection chronique par le virus de l'hépatite C et le risque d'adénocarcinome canalaire du pancréas (33 451 cas)
Pancreatic cancer is fatal, and only 1 of 10 patients can survive beyond 5 years after diagnosis. The best way to combat pancreatic cancer is to prevent it through identifying modifiable risk factors, and viruses are of particular interest since they have been reported to cause several cancers. Hepatitis C, a viral infection, currently affects 4 million people in the US. Hepatitis C virus (HCV) infection used to be difficult to treat, but it is now curable owing to recent treatment breakthroughs, such as direct-acting antivirals (DAAs): 95% or more of patients with HCV infection can be cured after taking DAAs for 8 to 12 weeks. There has been longstanding interest in whether HCV infection may contribute to an increased risk of pancreatic cancer. In addition, considering HCV’s genetic diversity (8 genotypes) and their differing disease progression, it is of clinical importance to examine the associations of HCV infection with pancreatic cancer risk by HCV genotypes.
JAMA Network Open , éditorial en libre accès, 2025