Tumor-infiltrating B cells participate in shaping the immunosuppressive microenvironment in solid tumors
Cet article examine l'hétérogénéité des lymphocytes B infiltrant les tumeurs (TIB), en particulier leurs voies de différenciation ainsi que le rôle des centres germinatifs et extrafolliculaires dans la régulation immunitaire, puis présente les différentes fonctions des TIB dans l'immunité tumorale
Tumor-infiltrating B cells (TIBs) exhibit dual roles in the tumor microenvironment (TME) of solid tumors. While they can enhance anti-tumor immunity through antibody production and immune activation, certain subsets—such as regulatory B cells (Bregs) and immunosuppressive plasma cells—contribute to immune evasion by secreting inhibitory factors. In this review, we analyze TIB heterogeneity, with a particular focus on their differentiation pathways, including the distinct roles of germinal center (GC) and extrafollicular (EF) responses in immune regulation. We further summarize the diverse functions of TIBs in tumor immunity, exploring their metabolic adaptations and defects in antibody maturation. A deeper understanding of TIB biology and their underlying mechanisms may pave the way for more precise and effective immunotherapeutic strategies against cancer.
International Journal of Cancer , article en libre accès, 2025