Regular physical inactivity and ovarian cancer risk in the Ovarian Cancer in Women of African Ancestry (OCWAA) Consortium
Menée à partir de données portant sur 7 684 témoins et 1 208 patientes atteintes d'un cancer de l'ovaire, cette étude analyse l'association entre une inactivité physique régulière et le risque de développer la maladie en fonction de l'origine ethnique
Background: Regular physical inactivity may increase ovarian cancer risk, but few studies have investigated whether this association is similar among Black and White women.
Methods: In a pooled nested case-control within the Ovarian Cancer in Women of African Ancestry consortium, logistic regression models evaluated regular recreational physical inactivity with risk of epithelial ovarian cancer among Black (223 cases; 1,472 controls) and White women (985 cases; 6,212 controls) enrolled in four cohort studies. Models were further stratified by histological type.
Results: Regular physical inactivity was not associated with risk of overall ovarian cancer among Black (OR=1.16, 95% confidence interval (CI): 0.83-1.61) or White women (OR=1.03, 95% CI: 0.87-1.23). We did not detect associations according to histological type.
Conclusions: Physical inactivity was not associated with ovarian cancer among Black or White women in a consortium of cohort studies.
Impact: These results are counter to case control-based studies and emphasize the complexity of investigating physical activity prospectively.
Cancer Epidemiology, Biomarkers & Prevention , résumé, 2025