Patient-Reported Outcomes—The Missing Variable in Survival Prediction
A partir d'une revue systématique de la littérature publiée entre 2000 et 2024 (69 essais cliniques incluant au total 44 030 patients), cette méta-analyse évalue l'association entre les résultats rapportés par les patients atteints d'un cancer (symptômes, statut fonctionnel et qualité de vie) et la survie globale
Huang et al herein present a systematic review and meta-analysis addressing an important question of whether patient-reported outcomes (PROs) provide prognostic information for patients with cancer. Their systematic review identified 69 randomized clinical trials (RCTs) including 44 030 patients. A subset of 31 RCTs were included in a meta-analysis to further evaluate the independent association between PROs and overall survival (OS). They found that global health status, physical functioning, and role functioning were independently associated with improved OS and that worsening symptoms (ie, nausea, vomiting, pain, fatigue, loss of appetite, dyspnea) were also associated with worse OS.
JAMA Oncology , éditorial, 2025