The impact of the immunological context on outcomes of solid cancer patients treated with genotype-matched targeted therapies: a comprehensive review
Menée à partir d'une revue de la littérature, cette étude examine, chez les patients atteints d'une tumeur solide, l'impact des caractéristiques immunologiques de la tumeur sur les résultats des thérapies ciblées
Introduction : Outcomes with genotype-matched targeted therapy in solid cancer patients are heterogeneous: some have exceptional responses, others primary progression. This review explores the immunobiological features which may underlie this differential response.
Methods : We conducted a literature review of studies assessing impact of immune context following searches on Web of Science, Medline and Embase. Relevant outcomes include response, progression-free survival and overall survival. Data was extracted from multivariate analysis, univariate analysis or directly from Kaplan-Meier curves. Meta-analyses were performed where three or more studies analysed the same immune factor for the same cancer type. Remaining studies were analysed descriptively.
Results : In the adjuvant setting assessment of the immune context does not highlight a group failing to derive benefit for the use of dabrafenib/trametinib after resection of BRAFV600E melanoma Differential gene expression in exceptional responders show enrichment of genes associated with immune activation. BRAFV600E colorectal cancer patients with high cytolytic scores benefit from the addition of MEK inhibition whereas those with low scores fare better without. High PD-L1 expression is predictive of inferior outcomes to EGFR, ALK and G12C tyrosine kinase inhibitors. EGFR-mutant patients with high CD8+ T cells and PD-L1 positivity have very poor outcomes. Stromal tumour-infiltrating lymphocytes predicts for efficacy of stromal-poor tumours in HER-2+ breast cancer treated with short-course adjuvant trastuzumab. High immune metagene and single immune gene expression is predictive of benefit for chemotherapy plus trastuzumab, but not chemotherapy alone. The addition of pertuzumab or lapatanib appears to be beneficial in those with immune non-enriched microenvironments. High MHCI is negatively and high MHCII positively predictive of outcome with trastuzumab-based therapy.
Conclusion : To our knowledge, this is the first review assessing immunological context as biomarker for targeted therapy. The results of this review represent an important resource to aid future translational studies in advancing stratified precision medicine oncology.
Annals of Oncology , article en libre accès, 2025