Selenium and Vitamin E Supplementation Above Recommended Dietary Intake May Increase Prostate Cancer Risk
Menée aux Etats-Unis, cette étude cas-cohorte (2 228 cas et 3 117 participants dans la cohorte randomisée) évalue les effets d'une supplémentation en sélénium et en vitamine E sur le risque de cancer de la prostate
In a large clinical trial testing dietary supplements for prostate cancer (PCa) prevention, baseline selenium (Se) status (measured by toenail Se concentration), in the absence of supplementation, was not associated with prostate cancer (PCa) risk. However, when baseline toenail Se concentrations were high, supplementation with high-dose Se almost doubled the risk of high-grade PCa risk among older men, according to a new study published February 21 in the Journal of the National Cancer Institute. High-dose vitamin E also more than doubled the risk high-grade PCa risk, but only among men with low baseline toenail Se concentrations
Journal of the National Cancer Institute , communiqué de presse, 2014