Leading Cancer Deaths in People Younger Than 50 Years
Menée à partir de données des registres américains des cancers, cette étude estime, pour la période 1990-2023, le risque de décès par cancer chez les patients âgés de moins de 50 ans
Numerous studies report increasing cancer incidence in young adults,1 but mortality trends are an important measure of progress against cancer that are less affected by detection bias. This study examined changes in cancer mortality in the US for the 5 leading cancer-related deaths among people younger than 50 years over the past 3 decades.
Annual numbers of cancer deaths and age-standardized rates per 100 000 males and females younger than 50 years from 1990 through 2023 were obtained from SEER*Stat (version 9.0.41.4; National Cancer Institute) as reported by the National Center for Health Statistics (NCHS). NCHS mortality data are based on underlying cause of death reported on death certificates filed in all 50 US states and the District of Columbia and were classified according to the International Classification of Diseases and Related Health Problems, Tenth Revision. Trends in rates for all cancer deaths combined and for the 5 leadinath from 1990 through 2023 were quantified using the Joinpoint Regression Program (version 5.4.0.0; National Cancer Institute), which uses permutation analysis to fit a series of straight lines on a logarithmic scale to observed rates to estimate annual percent change (APC). Mean APC during the past 10 data years (2014-2023) was also calculated. Trends were described as increasing or decreasing when the APC or mean APC was significantly different from zero (P < .05) using a 2-sided test. This study did not require institutional review board approval or informed consent based on guidelines from the National Advisory Committee of Human Research Protections because it involved only deidentified public-use data. We followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline.
JAMA , résumé, 2026