Achieving Healthy Weights for Improving Breast Cancer Prognosis
Mené aux Etats-Unis et au Canada sur 3 180 patientes atteintes d'un cancer du sein de stade II/III et souffrant d'obésité, cet essai randomisé de phase III évalue l'efficacité d'une intervention menée par téléphone pour aider à la perte de poids
Women with breast cancer and overweight or obesity have poorer outcomes, including lower overall survival, disease-free survival, and higher recurrence rates, compared with women with lighter weights. A 2023 meta-analysis of 39 observational studies showed that for each 5 mg/kg2 increase in body mass index (BMI), breast cancer–specific mortality rose by 10% (hazard ratio [HR], 1.10 [95% CI, 1.06-1.14]) and recurrence risk rose by 5% (HR, 1.05 [95% CI, 1.03-1.08])1 An earlier meta-analysis of 27 studies concluded that disease-free survival and overall survival are worse for women with obesity in all breast cancer subtypes studied (hormone receptor–positive/ERBB2-negative, ERBB2-positive, and triple-negative breast cancers), while overweight was not statistically significantly associated with prognosis.2 Meta-analyses of observational studies have also found that increased physical activity is associated with reduced breast cancer mortality and recurrence.3 Despite the large literature showing adverse associations of overweight and obesity on breast cancer prognosis, little is known about weight loss effects in this population.
JAMA Oncology , éditorial, 2025