Immunotherapy combined with radiotherapy in the treatment of lung cancer: a meta-analysis of therapeutic effectiveness, safety considerations, and abscopal effect
A partir d'une revue systématique de la littérature publiée jusqu'en mars 2024 (19 articles, 9 795 patients), cette méta-analyse évalue les différences thérapeutiques entre une immunothérapie par inhibiteurs de point de contrôle immunitaire associée à une radiothérapie et une immunothérapie traditionnelle seule pour un cancer du poumon
With the escalating global incidence and mortality of lung cancer, immunotherapy has achieved modest success while facing persistent challenges. The immunomodulatory effect of radiotherapy has gradually gained attention, especially the abscopal effect observed in the combination of radiotherapy and immunotherapy. Although mechanistically controversial, its clinical significance in lung cancer treatment is noteworthy. Therefore, this study aims to delve into the therapeutic differences between immunotherapy using immune checkpoint inhibitors (ICI) combined with radiotherapy (RT) and traditional immunotherapy alone, aiming to provide scientific evidence for optimizing lung cancer treatment strategies, improving patient outcomes, and enhancing survival rates.
BMC Cancer , article en libre accès, 2025