Leisure-time physical activity after diagnosis and survival by cancer type: a pooled analysis
Menée à partir des données de six études de cohorte incluant 90 844 patients atteints d'un cancer (11 localisations), cette étude analyse l'association entre la pratique, après le diagnostic, d'une activité physique de loisir et la survie en fonction de la localisation
Purpose: Evidence for potential mortality benefits of leisure-time moderate-to-vigorous intensity physical activity (MVPA) for survivors of cancer types beyond breast and colorectal is limited. The aim of this study was to evaluate relationships between postdiagnosis MVPA and all-cause mortality in participants with a history of eleven cancer types.
Methods: Data were pooled from six United States-based cohort studies. Cohort-specific hazard ratios and 95% confidence intervals (HR, CI) for associations of MVPA assessed ≥1-year after a cancer diagnosis and all-cause mortality were calculated using multivariable Cox proportional hazards models and then pooled using random effects meta-analysis. Models were adjusted for age, sex, race/ethnicity, smoking status, alcohol use, cancer treatment and stage. The sample included 90,844 cancer survivors (mean [standard deviation] age at diagnosis = 67 [10] years, 55% women), among whom 45,477 died during 10.9 [7.0] years of follow-up.
Results: Compared to no MVPA, engaging in recommended amounts of MVPA (7.5-<15 MET-hr./wk.) was related to better overall survival in participants with a history of one of ten cancer types: oral (HR = 0.44, 0.27-0.73), endometrial (0.50, 0.34-0.76), lung (0.51, 0.38-0.68), rectal (0.51, 0.36-0.71), respiratory (0.51, 0.29-0.72), bladder (0.53, 0.40-0.72), kidney (0.53, 0.37-0.77), prostate (0.60, 0.49-0.74), colon (0.61, 0.50-0.76), and breast (0.67, 0.55-0.81). Eight of the ten observed inverse associations remained similar when excluding participants who died within two years of follow-up.
Conclusion: Engaging in leisure-time MVPA after a cancer diagnosis appears to improve survival for people with a history of several cancer types, including bladder, breast, colon, endometrial, kidney, lung, oral, prostate, rectal, and respiratory cancer.
Journal of the National Cancer Institute , résumé, 2025