Anti-Inflammatory Diet Index and risk of renal cell carcinoma
Menée à l'aide de données de 2 cohortes suédoises portant sur 71 421 personnes (durée de suivi : 19,7 ans), cette étude analyse l'association entre un régime anti-inflammatoire et le risque de carcinome à cellules rénales (431 cas) en fonction du sexe
Introduction: A diet rich in fruits, vegetables, coffee, and tea, limited red meat, and moderate alcohol intake may reduce the risk of renal cell carcinoma (RCC). The anti-inflammatory potential of diet has been proposed as a mechanism influencing cancer risk. This study assessed the association between an anti-inflammatory diet and RCC risk.
Methodology: Data from two Swedish cohorts, the Swedish-Mammography-Cohort and the Cohort-of-Swedish-Men, were analysed. Dietary habits were assessed using a 96-item food frequency questionnaire. The Anti-Inflammatory Diet Index (AIDI), composed of 16 food groups (11 anti-inflammatory and 5 pro-inflammatory), was used to score dietary patterns. RCC cases were identified from the Swedish Cancer Register using ICD-10 codes, and Cox proportional hazards models were used to estimate hazard ratios based on AIDI quartiles.
Results: Among 71,421 participants, 431 RCC cases were identified during a 19.7-year follow-up. Higher AIDI scores were associated with a lower RCC risk (HR for Q4 vs. Q1: 0.68, CI: 0.52–0.89). In sex-stratified analyses (p-for heterogeneity = 0.006), the association was stronger in among women (HR: 0.47, CI: 0.30–0.75) but less clear in among men (HR: 0.83, CI: 0.63–1.24).
Conclusion: These data suggest that adherence to an anti-inflammatory diet may confer a reduced risk for RCC, especially among women.
British Journal of Cancer , article en libre accès, 2025