Organized cervical cancer screening: A randomized controlled trial assessing the effect of sending invitation letters
Mené en France auprès de 148 510 femmes âgées de 40 à 65 ans et auprès de 1 070 médecins généralistes, cet essai évalue l'effet, sur le taux de participation, de deux modalités du programme de dépistage du cancer du col de l'utérus
Objective : To evaluate the effect of implementing two modalities of organized Cervical Cancer Screening (CCS) program on screening uptake after a six-month delay.
Methods : A three-armed cluster randomized control trial was conducted in France between January 8 and July 2, 2021, involving 148 510 women aged 40 to 65 and 1070 general practitioners.
In the Optimized screening group, an invitation letter was posted to non-adherent women, and general practitioners were sent a list of their non-adherent patients. In the Organized screening group, an invitation letter was posted to non-adherent women. In the Usual care group, no invitation was sent. The endpoint was cervical cancer screening uptake after a six months period a) among all eligible women (primary endpoint); and b) among initially non-adherent women (post-hoc analysis). Statistical analysis was based on a logistic mixed model that compared between-group percentages of adherent women. A hierarchical comparison successively tested differences between the three arms (alpha 5 % risk).
Results : Among all 148,510 eligible women, screening uptake was 63.6 % (31,731/49910) in the Optimized screening group vs 61.8 % (30,210/48847) in the Usual care group (OR [IC95 %] = 1.05[0.93; 1.18]).
Among the 64,370 initially non-adherent women, screening uptake was 17.9 % (3955/22134) in the Optimized screening group vs 11.6 % (5321/20995) in the Usual care group (OR [IC95 %] = 1.70[1.56;1.86]). There was no significant difference between Optimized and Organized screening groups (17.2 % vs 17.9 %; OR [IC95 %] = 1.02[0.94; 1.11]).
Conclusions : The implementation of an organized screening based on an invitation letter resulted in a modest increase in participation among non-adherent women six months later.
Preventive Medicine , article en libre accès, 2024