Transperineal vs Transrectal Prostate Biopsy—The PREVENT Randomized Clinical Trial
Mené sur 875 patients avec suspicion de cancer de la prostate, cet essai évalue l'intérêt, du point de vue du taux de détection et du taux d'infections, d'une biopsie prostatique transpérinéale par rapport à une biopsie transrectale
Prostate biopsy is a common and invasive diagnostic procedure. First-time biopsy detects prostate cancer in more than half of patients, and many with a benign initial biopsy or those receiving active surveillance undergo repeated biopsies. With the international incidence at 1.4 million prostate cancer cases, more than 3 million prostate biopsies are performed annually. Transrectal prostate biopsy is the predominant approach used and antibiotics are given routinely to prevent infection, which increases societal antimicrobial resistance.Recently, an alternative transperineal biopsy approach under local anesthesia has increased in use. During this biopsy approach, the needle traverses the cleaned skin of the perineum. Although there are potential advantages to transperineal biopsy, high-level evidence is limited. We reported a funder-mandated interim analysis, and now present the final results after meeting the sample size requirement (369 participants per group).
JAMA Oncology , résumé, 2023