Long-Term survival across breslow thickness categories: Findings from a Population-Based study of 210,042 Australian melanoma patients
Menée à partir de données d'un registre australien portant sur 210 042 patients atteints d'un mélanome cutané primitif diagnostiqué entre 1982 et 2014, cette étude évalue le taux de décès pour chaque catégorie d'épaisseur Breslow du système de stadification de l'"American Joint Committee on Cancer" (8ème édition)
The prognosis of a patient with a primary cutaneous melanoma is known to be related to the Breslow thickness of their tumor. This study sought to determine long-term (30-year) survival rates for the four AJCC 8th Edition T-categories by analyzing Australian registry data for 210,042 melanoma patients diagnosed from 1982-2014.The 30-year incidence rates of death due to melanoma and non-melanoma causes (with 95% confidence intervals) were 7.1% (CI 6.9-7.3%) and 32.8% (CI 32.3-33.3%), respectively. For T2 melanomas, the corresponding rates were 21.6% (CI 21.0-22.3%) and 35.6% (CI 34.7-36.6%), for T3 melanomas 34.2% (CI 33.4-35.1%) and 39.6% (CI 38.5-40.8%), and for T4 melanomas 44.3% (CI 43.2-45.3%) and 39.6% (CI 38.3-41.0%). A plateau in melanoma-related deaths occurred in T4 patients after 20 years but there were ongoing melanoma-related deaths for the other T-categories beyond 30 years. A progressive rise in the risk of death from other causes occurred across all T-categories.
Journal of the National Cancer Institute , article en libre accès, 2023