Association of breast cancer with quantitative mammographic density measures for women receiving contrast-enhanced mammography
Menée sur 66 patientes atteintes d'un cancer du sein et sur 133 témoins en bonne santé ayant toutes bénéficié d'une mammographie de dépistage avec rehaussement de contraste, cette étude évalue l'association entre des mesures quantitatives de densité mammographique et le risque de cancer mammaire
Women with high mammographic density (MD) have an increased risk of breast cancer. They may be offered contrast-enhanced mammogram (CEM) to improve breast cancer screening performance. Using a cohort of women receiving CEM, we evaluated whether conventional and modified MD measures were associated with breast cancer. Sixty-six cases with newly diagnosed unilateral breast cancer were frequency-matched on age to 133 cancer-free controls. On low-energy cranio-caudal CEMs (equivalent to standard mammogram), we measured quantitative MD using CUMULUS software at the conventional intensity threshold (“Cumulus”) and higher-than-conventional thresholds (“Altocumulus”, “Cirrocumulus”). The measures were standardized to enable estimation of odds per age- and adiposity-adjusted standard deviation (OPERA). In multivariable logistic regression of case-control status, only the highest-intensity measure, Cirrocumulus, was statistically significantly associated with breast cancer (OPERA = 1.40, 95% CI 1.04-1.89). Conventional Cumulus did not contribute to model fit. For women receiving CEM, Cirrocumulus MD might better predict breast cancer than conventional quantitative MD.
JNCI Cancer Spectrum , article en libre accès, 2023