Genetic risk and likelihood of prostate cancer detection on first biopsy by ancestry
Menée à partir de données portant sur 36 717 hommes dont 10 297 d'ascendance africaine, cette étude évalue, en fonction de l'origine ethnique (européenne ou africaine), l'association entre un score de risque génétique et la probabilité de détecter un cancer de la prostate à la première biopsie
Despite differences in prostate cancer risk across ancestry groups, relative performance of prostate cancer genetic risks scores (GRS) for positive biopsy prediction in different ancestry groups is unknown. This cross-sectional retrospective analysis examines the association between a polygenic hazard score (PHS290) and risk of prostate cancer diagnosis upon first biopsy in male Veterans using two-sided tests. Our analysis included 36,717 Veterans (10,297 of African ancestry). Unadjusted rates of positive first prostate biopsy increased with higher genetic risk (low risk: 34%, high risk: 58%; p < .001). Among men of African ancestry, higher genetic risk was associated with increased prostate cancer detection on first biopsy (OR 2.18, 95% CI 1.93-2.47), but the effect was stronger among men of European descent (OR 3.89, 95% CI 3.62-4.18). These findings suggest that incorporating genetic risk into prediction models could better personalize biopsy decisions, although further study is needed to achieve equitable genetic risk stratification among ancestry groups.
Journal of the National Cancer Institute , article en libre accès, 2023