Promise of bile circulating tumor DNA in biliary tract cancers
Menée à partir d'échantillons plasmatiques et d'échantillons biliaires prélevés sur des patients atteints d'un cancer pancréaticobiliaire, cette étude compare l'intérêt de ces deux types d'échantillons pour extraire de l'ADN tumoral circulant et identifier des mutations oncogènes ainsi que des mutations pouvant constituer une cible thérapeutique
Anexplosion of technological advances has facilitated the unprecedented use of liquid biopsy methods to isolate and interrogate circulating tumor DNA (ctDNA) for precision oncology approaches. Liquid biopsy samples are not isolated to plasma but include bodily fluids such as urine and bile. In this issue, Ohyama et al. present a prospective study of patients with biliary tract cancers who underwent cell-free DNA (cfDNA) isolation from bile and plasma, further demonstrating the feasibility and promise of bile cfDNA for biliary tract malignancies.
Cancer , éditorial, 2022