Initiating the Era of “Precision” Lung Cancer Surgery
Mené entre 2007 et 2017 sur 697 patients atteints d'un cancer du poumon périphérique non à petites cellules de stade T1aN0 (durée médiane de suivi : 7 ans), cet essai randomisé de phase III évalue la non-infériorité, du point de vue de la survie sans maladie, d'une résection sous-lobaire par rapport à une lobectomie
Surgical resection for lung cancer dates to the early 20th century. Evarts Graham is credited with performing the first successful pneumonectomy in 1933 for what was then an uncommon disease. During the next 25 years, surgeons focused on improving outcomes through better resection techniques. In 1962, retrospective data suggested that lobectomy for early-stage non–small-cell lung cancer (NSCLC) yielded a 5-year overall survival similar to that reported after pneumonectomy,1 and lobectomy gradually became the more commonly performed operation.
New England Journal of Medicine , éditorial, 2022