Associations of Genetic Ancestry with Terminal Duct Lobular Unit Involution among Healthy Women
Menée à partir de l'analyse de tissus mammaires issus de 2 014 femmes en bonne santé, cette étude évalue l'association entre leur origine ethnique et l'involution de l'unité terminale ductulo-lobulaire, un facteur associé au risque de cancer du sein
Reduced age-related terminal duct lobular unit (TDLU) involution has been linked to increased breast cancer risk and triple-negative breast cancer (TNBC). Associations of TDLU involution levels with race and ethnicity remain incompletely explored. Herein, we examined associations between genetic ancestry and TDLU involution in normal breast tissue donated by 2,014 healthy women in the US. Women of African ancestry were more likely than European women to have increased TDLU counts (odds ratio [OR]trend=1.36; 95% CI = 1.07–1.74), acini counts/TDLU (OR = 1.47; 95% CI = 1.06–2.03), and median TDLU span (ORtrend=1.44; 95% CI = 1.08–1.91), indicating lower involution; whereas East Asian descendants were associated with decreased TDLU counts (ORtrend=0.52; 95% CI = 0.35–0.78) after controlling for potential confounders. These associations are consistent with the racial variations in incidence rates of TNBC in the US and suggest opportunities for future work examining whether TDLU involution may mediate the racial differences in subtype-specific breast cancer risk.
Journal of the National Cancer Institute , article en libre accès, 2021