Exposure Histories and Cancer Risk—What Can We Learn?
Menée en Allemagne auprès de 4 515 témoins et 5 635 patients atteints d'un cancer colorectal (âge moyen : 68,4 ans ; 61 % d'hommes), cette étude analyse l'association entre un excès de poids cumulé au cours de la vie et le risque de développer la maladie
In this issue of JAMA Oncology, Li et al present findings from a large case-control study of the association of weight history with colorectal cancer risk. The primary analysis used weighted number of years with overweight or obesity (WYOs), calculated as excess body mass index (eBMI, defined as BMI [calculated as weight in kilograms divided by height in meters squared] − 25, truncated 0) accumulated from age 20 years to the index date. The authors observed a consistent association between WYOs and colorectal cancer risk, with seemingly more pronounced associations than similar analyses using age-specific eBMI or untransformed BMI measures. While these results are intriguing, it is important to examine the broader meaning and implications of such measures.
JAMA Oncology , éditorial, 2021