Impact of Exercise on Susceptibility and Severity of COVID-19 in Patients with Cancer: A Retrospective Study
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Background. Modifiable lifestyle-related factors heighten the risk and severity of coronavirus disease 2019 (COVID-19) in patients with cancer. Whether exercise lowers susceptibility or severity is not known.
Methods. We identified 944 cancer patients from Memorial Sloan Kettering Cancer Center (mean age: 64; 85% female; 78% White) completing an exercise survey before receiving a confirmed positive or negative SARS-CoV-2 test. Exercise was defined as reporting moderate-intensity
5 days per week,
30 minutes/session or strenuous-intensity
3 days per week,
20 minutes/session. Multivariable logistic regression was used to determine the relationship between exercise and COVID-19 susceptibility and severity (i.e., composite of hospital admission or death events) with adjustment for clinical-epidemiologic covariates.
Results. Twenty-four percent (230 / 944) of the overall cohort were diagnosed with COVID-19 and 35% (333 / 944) were exercisers. During a median follow-up of 10 months, 26% (156 / 611) of non-exercising patients were diagnosed with COVID-19 compared with 22% (74 / 333) of exercising patients. The adjusted odds ratio (OR) for risk of COVID-19 was 0.65 (95% CI: 0.44 to 0.96, p=0.03) for exercisers compared to non-exercisers. A total of 20% (47 / 230) of COVID-19 positive patients were hospitalized or died. No difference in the risk of severe COVID-19 as a function of exercise status was observed (p>0.9).
Conclusion: Exercise may reduce the risk of COVID-19 infection in patients with a history of cancer, but not its severity.
Impact. This study provides the first data showing that exercise might lower the risk of COVID-19 in cancer patients, but further research is required.
Cancer Epidemiology, Biomarkers & Prevention , résumé, 2021