Rs708113 in WNT3A-WNT9A and hepatocellular carcinoma risk
Menée auprès d'une cohorte de 775 patients atteints d'un carcinome hépatique lié à l'alcool et 1 332 témoins, puis validée auprès de 874 patients et 1 059 témoins, cette étude d'association sur le génome entier identifie un locus de susceptibilité à la maladie
Hepatocellular carcinoma is the most frequent primary liver malignancy and fourth most common cause of cancer-related mortality worldwide. 1 Although chronic viral hepatitis, particularly due to hepatitis B virus (HBV) infection, is the most common underlying liver disease leading to hepatocellular carcinoma in southeast Asia, alcohol-related liver disease and non-alcoholic fatty liver disease are the predominant causes in Europe and North America. Alcohol-related liver disease and non-alcoholic fatty liver disease are expected to become the leading causes of hepatocellular carcinoma in the future, with HBV and hepatitis C virus infections declining as a result of effective vaccination strategies and treatments. With few exceptions, most hepatocellular carcinoma cases in high-income countries develop in patients with established cirrhosis; alcohol-related cirrhosis is the second most common risk factor for hepatocellular carcinoma in high-income countries, 2 with an annual risk of hepatocellular carcinoma of up to 2·5%. 3 Alcohol-related hepatocellular carcinoma is a complex disease, but easily discernible clinical risk factors include type 2 diabetes, obesity, and older age.
The Lancet Oncology , commentaire, 2020