Breast Cancer Microenvironment Cross Talk through Extracellular Vesicle RNAs
Cet article passe en revue les études concernant les interactions cellulaires, via les ARNs des vésicules extracellulaires, dans le microenvironnement des tumeurs mammaires
Exploration of extracellular communication has been at the forefront of research efforts in recent years. However, the mechanisms of cell-to-cell communication in complex tissues are poorly understood. What is clear is that cells do not exist in isolation, that they are constantly interacting and communicating with cells in the immediate vicinity and with cells at a distance. Intercellular communication by the release of small extracellular vesicles, called exosomes, loaded with RNAs is one mechanism by which cells communicate. Research in recent years has shown that exosomes, a class of extracellular vesicles, can play a major role in the pathogenesis of breast cancer. Specifically, exosomes have been demonstrated to play a role in promoting primary cancer development, invasion, metastasis, and chemotherapeutic resistance. This review will summarize what is known about the mechanisms of exosome-mediated transfer of RNAs among cells in the breast microenvironment, will discuss outstanding questions, and the potential for new therapeutic intervention targeted at these interactions.
The American Journal of Pathology , résumé, 2020