Evaluation of a Multiethnic Polygenic Risk Score Model for Prostate Cancer
Menée aux Etats-Unis auprès de 1 643 hommes atteints d'un cancer de la prostate et 11 985 témoins, cette étude évalue, en fonction de l'origine ethnique, l'association entre un système de score, basé sur la présence de 261 variants génétiques constitutionnels, et le risque de développer la maladie
Polygenic risk scores (PRS) of common genetic variants have shown promise in prostate cancer risk stratification, but their validity across populations has yet to be confirmed. We evaluated a multiethnic PRS model based on 269 germline genetic risk variants (261 were available for analysis) using an independent population of 13,628 U.S. men. The PRS was strongly associated with prostate cancer, but not with any other disease. Comparing men in the top PRS decile to those at average risk (40%–60%), the odds ratio of prostate cancer was 3.89 (95% confidence interval = 3.24 to 4.68) for men of European ancestry and 3.81 (95% confidence interval = 1.48 to 10.19) for men of African ancestry. By age 85, the cumulative incidence of prostate cancer for European American men was 7.1% in the bottom and 54.1% in the top decile. This suggests that the PRS can be used to identify a substantial proportion of men at high risk for prostate cancer.
Journal of the National Cancer Institute , article en libre accès, 2020