Clinical Characteristics of Patients with Pancreatic Cancer and Pathogenic ATM Alterations
Menée à partir de données portant sur 66 patients atteints d'un adénocarcinome canalaire du pancréas, cette étude identifie les caractéristiques cliniques des patients présentant des altérations au niveau du gène ATM
The Ataxia-Telangiesctasia mutated (ATM) gene is involved in a number of DNA damage repair pathways and confers an increased risk for pancreatic ductal adenocarcinoma (PDAC). In this retrospective study, we identified and profiled 22 patients with PDAC and a known somatic or germline pathogenic ATM alteration (cases). These patients were matched 2:1 by age, stage and year at diagnosis to patients with PDAC patients without known ATM alterations. The median overall survival in patients with ATM alterations was 40.2 months compared to 15.5 months in the control population (hazard ratio = 0.14, 95% confidence interval = 0.04 to 0.47, two-sided p = .001). In multivariate analysis, these findings persisted after adjustment for receipt of platinum therapy and ECOG status. These findings suggest that pathogenic ATM alterations may be prognostic for improved outcomes in patients with pancreatic cancer.
JNCI Cancer Spectrum , article en libre accès, 2020