Poverty and Survival in Childhood Cancer: A Framework to Move Toward Systemic Change
Menée aux Etats-Unis à partir de données portant sur 371 enfants atteints d'un neuroblastome à haut risque de récidive traité par immunothérapie, cette étude de cohorte rétrospective analyse l'association entre la pauvreté du voisinage et du foyer, la survie sans événement et la survie globale
As cure rates have risen among children with cancer, racial and ethnic disparities in cancer-related outcomes have become apparent (1-14). Although biology explains a portion of these disparities (15,16), it is evident that socioeconomic status (SES) is associated with outcome (1-4, 6-14) and mediates the effect of race and ethnicity in acute leukemias, lymphomas, and neuroblastoma (5). These SES studies often used population-level data without the granularity to understand how the complex multilayered construct of poverty influences survival, thus lacking pragmatic application. A holistic approach that considers neighborhood- and household-level poverty alongside individual factors is necessary to understand the interplay of poverty and cancer-related outcomes in children.
Journal of the National Cancer Institute , éditorial, 2019