The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer
Menée auprès de 188 patients atteints d'un cancer, cette étude met en évidence l'effet de l'obésité sur la consommation de glucose par les tumeurs mammaires et les tumeurs pulmonaires
Obesity confers an increased incidence and poorer clinical prognosis in over ten cancer types. Paradoxically, obesity provides protection from poor outcomes in lung cancer. Mechanisms for the obesity-cancer links are not fully elucidated, with altered glucose metabolism being a promising candidate. Using 18F-Fluorodeoxyglucose positron-emission-tomography/computed-tomography images from The Cancer Imaging Archive, we explored the relationship between body mass index (BMI) and glucose metabolism in several cancers. In 188 patients (BMI: 27.7, SD = 5.1, Range = 17.4-49.3 kg/m2), higher BMI was associated with greater tumor glucose uptake in obesity-associated breast cancer r = 0.36, p = 0.02), and with lower tumor glucose uptake in non-small-cell lung cancer (r=-0.26, p = 0.048) using two-sided Pearson correlations. No relationship was observed in soft tissue sarcoma or squamous cell carcinoma. Harnessing The National Cancer Institute’s open-access database, we demonstrate altered tumor glucose metabolism as a potential mechanism for the detrimental and protective effects of obesity on breast and lung cancer, respectively.
JNCI Cancer Spectrum , article en libre accès, 2019