Unlocking the secret of the obesity paradox in renal tumours
Menée à partir de données génétiques portant sur trois cohortes incluant au total 478 patients adultes atteints d'un carcinome rénal à cellules claires, cette étude analyse la relation entre l'indice de masse corporelle, les caractéristiques du microenvironnement tumoral et la survie des patients
The obesity paradox refers to the correlation between obesity and improved oncological outcomes in patients with advanced cancer, despite the fact that metabolically healthy obese individuals have an increased risk of developing cancer in the first place. In The Lancet Oncology, Alejandro Sanchez and colleagues 1
investigated the transcriptomic profile of tumours within the context of the obesity paradox in patients with clear cell renal cell carcinoma (RCC). They investigated the angiogenic and immunological transcriptomic profiles of tumours and perinephric adipose tissue in patients with a normal weight (ie, with a body-mass index [BMI] 18·5–24·9 kg/m 2, as per WHO's BMI categories) and in obese patients (BMI ≥30 kg/m 2) in five cohorts of patients with clear cell RCC.
The Lancet Oncology , commentaire, 2018