From Peyton Rous to the HPV Vaccine: A Journey of Discovery and Progress
Ces articles évaluent la sécurité du vaccin quadrivalent contre le papillomavirus humain du point de vue des effets indésirables enregistrés aux Etats-Unis
Peyton Rous began his famous experiments in 1909 at the Rockefeller Institute, demonstrating that a sarcoma on the chest of a Plymouth Rock hen that had been brought to him by a farmer from Long Island, New York, could be transplanted to other chickens. Because cell-free tumor extracts resulted in transmission of the sarcoma to other hens, he postulated the agent must be a small transmissible agent, possibly a virus.1 The concept that a virus might cause cancer was outside the prevailing concepts of the time, and his postulate languished for years.
Pediatrics , commentaire en libre accès, 2018