Breast cancer screening in high-risk women: is MRI alone enough?
Menée au Canada auprès de 8 782 femmes présentant un risque élevé de cancer du sein et participant à un programme de dépistage (âge: 30 à 69 ans), cette étude évalue l'efficacité, du point de vue des taux de détection, de la sensibilité et de la spécificité, d'une IRM et d'une mammographie, combinées ou non, en fonction de catégories d'âge et de critères de risque
Breast magnetic resonance imaging (MRI) is considered the most sensitive imaging modality fortheearly detection of breast cancer. The American Cancer Society guidelines and the National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology recommend annual breast MRI screening for women at high risk for breast cancer, which include BRCA mutation carriers and their untested first-degreerelatives ; women with Li-Fraumenisyndromeand other high-risk predisposition syndromes; womenwith a history of thoracic radiation therapy between age 10to 30; and women with 20% or greater lifetime risk of breast cancer based on risk assessment models. Annual MRI screening should startatage 25–30 and annual mammography screening is also recommended, starting preferably at age 30.
Journal of the National Cancer Institute , éditorial en libre accès, 2018