Oestrogen receptor status and survival in women with BRCA2-associated breast cancer
Menée à partir de données sur 390 femmes porteuses d'une mutation BRCA2 et atteintes d'un cancer du sein diagnostiqué entre 1975 et 2015 (durée moyenne de suivi : 12,3 ans), cette étude évalue l'effet du statut des récepteurs des estrogènes de la tumeur sur le taux de survie spécifique à 20 ans
Background : To evaluate the predictors of mortality, including ER status, in women with a BRCA2 mutation and breast cancer.
Methods : Eligible participants were identified from within two longitudinal cohorts. These patients were selected because they were diagnosed with breast cancer between 1975 and 2015 and carried a BRCA2 mutation. Data were abstracted from the medical record and pathology report. We analysed the effects of ER status and other variables on breast cancer specific survival using a Cox proportional hazards model.
Results : Three hundred ninety women with breast cancer and a BRCA2 mutation were included in the analysis. The mean follow-up time was 12.3 years (range 1–39 years) and 89 subjects died (22.8%). In the multivariate analysis, women with ER-positive tumours were more likely to die than women with ER-negative tumours (HR 2.08, 95% CI 0.99–4.36, p = 0.05), and this was of borderline significance. For the 233 women with ER-positive tumours the 20-year survival rate was 62.2%, compared to 83.7% for 58 women with ER-negative tumours (p = 0.03).
Conclusions : The majority of women with a BRCA2 mutation present with ER-positive breast cancer, and for these women, prognosis may be worse than for BRCA2 carriers with ER-negative breast cancer.
British Journal of Cancer , résumé, 2019