Non-epithelial ovarian cancer : ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Cet article présente les recommandations de l'"European Society for Medical Oncology" concernant le diagnostic, le traitement et le suivi d'un cancer de l'ovaire non épithélial
Non-epithelial ovarian tumours account for approximately 10% of all ovarian cancers. Malignant germ cell tumours (GCTs) occur mainly in young women whereas the most common type of sex cord-stromal tumours (SCSTs), i.e. granulosa cell tumour, occurs more often in middle age and in postmenopausal women [1]. Malignant GCTs represent 5% of all ovarian cancers and 80% of the preadolescent malignant ovarian tumours. SCSTs are rare neoplasms that account for approximately 3%–5% of ovarian malignancies and the majority of ovarian tumours with endocrine manifestations. The yearly-adjusted incidence rate is 3.7/1 000 000 and 2.1/1 000 000 women for GCTs and SCSTs, respectively [1]. Small cell carcinoma of the ovary (SCCO) usually affects young women and children [2] with a very low incidence (less than 1% of ovarian cancers) [1]. Unlike GCTs, SCSTs and steroid cell tumours are unilateral and occur over a wide range of age; for instance, granulosa cell tumours and thecomas are found mainly in peri- and postmenopausal women, whereas juvenile granulosa cell tumours, Sertoli cell tumours and Sertoli–Leydig cell tumours (SLCTs) usually develop in adolescents and young females in whom maintenance of fertility is important
Annals of Oncology , article en libre accès, 2017