The quest for optimal intraoperative colorectal cancer detection
Menée auprès d'une cohorte de 26 patients adultes atteints d'un cancer colorectal primitif devant être traité par résection, cette étude multicentrique évalue la tolérabilité d'un anticorps monoclonal fluorescent ciblant l'antigène carcino-embryonnaire, puis analyse la possibilité de détecter, à l'aide de l'imagerie par fluorescence, des tissus cancéreux durant l'intervention chirurgicale
The most important facet of successfully achieving curative colorectal cancer surgery is complete extirpation of all tumour to achieve an R0 resection. Unfortunately, tumour-cell deposits might postoperatively remain in vivo because of an inability to detect occult areas. Current preoperative staging modalities that try to preoperatively improve accuracy include CT scan, PET scan, and MRI. Intraoperative methods of tumour detection are generally limited to either palpation during open (laparotomy or hand-assisted) surgery or visualisation during minimally invasive (laparoscopic or robotic) surgery.
The Lancet Gastroenterology & Hepatology , commentaire, 2017