Surveillance of dutch patients with Li-Fraumeni syndrome: The LiFe-Guard study
Ce dossier présente un ensemble d'articles sur les stratégies de surveillance et le dépistage des cancers chez les personnes présentant une prédisposition génétique (syndrome de Lynch ou syndrome de Li-Fraumeni)
Li-Fraumeni syndrome is a rare cancer predisposition syndrome characterized by a high lifetime risk of developing different tumors including sarcomas, breast cancer, brain tumors, leukemia, and adrenal cortical carcinomas and is associated with germline mutations in the TP53 gene. An annual surveillance program including whole-body magnetic resonance imaging (WB-MRI) potentially benefits these patients.3,4 False-positive screening results, however, may pose a burden on patients and the health care system.
JAMA Oncology , résumé, 2016