Human papillomavirus triage of women with atypical squamous cells of undetermined significance—reduction of overtreatment needed
Menée aux Etats-Unis à partir de données portant sur 457 317 femmes ayant subi un test de dépistage du cancer du col de l'utérus entre 2007 et 2012 (âge moyen : 39,8 ans), cette étude analyse l'effet de l'utilisation du test HPV sur le taux de détection de lésions cervicales intra-épithéliales de grade 1 à 3, le taux de biopsies, le taux d'excision électrochirurgicale à l'anse et le délai avant confirmation histologique du diagnostic
The aim of cervical cancer screening is to prevent mortality and incidence of cervical cancer. Population-based cervical cancer screening by quality-assured cytology has led to a significant decrease in mortality and incidence of cervical cancer by early detection and treatment of cervical cancer precursor lesions and low stages of cancer. Histologically, precursor lesions of cervical cancer are classified as cervical intraepithelial neoplasia (CIN), graded from CIN1 to CIN3 according to the severity of the lesion, defined as the width of the cervical epithelium (one-third to full thickness) consisting of morphologically abnormal cells. The reproducibility of grading CIN lesions by pathologists is at best 70%.1
JAMA Oncology , éditorial en libre accès, 2016