Ensuring Vaccine Safety in Pregnant Women
Menée sur une cohorte danoise incluant 8 325 femmes enceintes, cette étude évalue l'association entre une vaccination quadrivalente contre le papillomavirus humain administrée par inadvertance durant une grossesse et le risque d'événements indésirables (avortement spontané, naissance prématurée, enfant mort-né, ...)
In this issue of the Journal, investigators from Denmark present a comprehensive review of the adverse pregnancy outcomes encountered in women who received quadrivalent human papillomavirus (HPV) vaccine during pregnancy, as compared with those who did not.1 The investigators assembled data on all the pregnancies in Denmark that occurred within a 7-year period, and they used nationwide registries to identify the dates of pregnancy, pregnancy outcomes, and maternal characteristics, including receipt of HPV vaccine and dates of vaccine administration. Vaccinated women and unvaccinated women were propensity-score matched in a 1:4 ratio, and pregnancy outcomes were compared. Although a large number . .
New England Journal of Medicine , éditorial, 2017